Y. Dalal

The Symmetry and Asymmetry Behind Histone Folding Across Eukarya and Archaea

The paper uses molecular dynamics and AI to show eukaryotic histones can form stable homodimers, with disordered tails favoring heterotypic dimers.

Single Molecule Analysis of CENP-A Chromatin by High-Speed Atomic Force Microscopy

The paper uses high-speed atomic force microscopy to analyze single-molecule dynamics of CENP-A nucleosomes and shows how CENP-C affects their mobility and chromatin accessibility.

Binding Dynamics of Disordered Linker Histone H1 with a Nucleosomal Particle

This study uses a computational model to show how disordered domains of H1 linker histone restrict chromatosome dynamics and enhance its structural rigidity.

The ratio between centromeric proteins CENP-A and CENP-C maintains homeostasis of human centromeres

The paper shows that maintaining the CENP-A to CENP-C ratio is critical for centromere homeostasis, as disrupting this balance causes mitotic defects.

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

The paper investigates how histone variants encode intrinsic elasticity in nucleosomes and how their binding partners modulate this elasticity and chromatin compaction.

The Oligomerization Landscape of Histones

This study uses molecular dynamics simulations to analyze the thermodynamic and dynamic properties of canonical and CENP-A histone tetramers, revealing structural differences and their implications for nucleosome assembly.

CENP-A associated lncRNAs influence chromosome segregation in human cells

This study identifies CENP-A associated lncRNAs transcribed from centromeres in early G1 phase and shows their functional role in chromosome segregation.

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

This study investigates how acetylation and methylation of CENP-A lysine 124 affect centromere dynamics, mitotic fidelity, and replication timing.