K. C. Neuman

Heterogeneous distribution of kinesin-streptavidin complexes revealed by Mass Photometry

The paper uses mass photometry to show heterogeneous distributions of kinesin-streptavidin complexes, attributing this to mixing ratios and biotinylation efficiency.

Cholesterol in the cargo membrane reduces kinesin-1 binding to microtubules in the presence of tau

The paper investigates how cholesterol in a cargo membrane affects kinesin-1 binding to microtubules in the presence of tau, showing that cholesterol enhances tau's inhibitory effect.

Single Molecule Analysis of CENP-A Chromatin by High-Speed Atomic Force Microscopy

The paper uses high-speed atomic force microscopy to analyze single-molecule dynamics of CENP-A nucleosomes and shows how CENP-C affects their mobility and chromatin accessibility.

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion

This study uses Nanopore Tweezers to measure RecQ helicase conformational changes, revealing an asymmetric energy landscape that allows it to maintain speed against opposing forces.

Topoisomerase VI is a chirally-selective, preferential DNA decatenase

This study shows that topoisomerase VI preferentially decatenates DNA crossings over relaxing supercoils by sensing specific DNA geometries.

CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

The paper investigates how CTP and parS modulate ParBF-ParAF complex assembly and ParA-ATPase activation in ParABS-mediated DNA partitioning.

Coarse-Grained Modelling of DNA Plectoneme Pinning in the Presence of Base-Pair Mismatches

This study uses coarse-grained MD simulations to show that DNA plectoneme pinning at mismatches is deterministic under high force and salt, but probabilistic under physiological conditions, with pinning probability increasing with mismatch size.

Direct Observation of Topoisomerase IA Gate Dynamics

This study directly observes the gate dynamics of E. coli type IA topoisomerases I and III using a single-molecule assay, revealing gate opening and force resistance.

Defect-Facilitated Buckling in Supercoiled Double-Helix DNA

The paper develops a statistical-mechanical model to study DNA buckling and plectoneme domain behavior under stretching forces and ionic conditions, showing defect-facilitated kink formation and energy reduction.