A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall
L. S. Marmont, A. K. Orta, R. A. Corey, D. Sychantha, A. Fernandez-Galliano, Y. E. Li, B. W. Baileeves, N. G. Greene, P. J. Stansfeld, W. M. Clemons, T. G. Bernhardt
This study identifies a feedback mechanism in bacterial cell wall synthesis where excess lipid II inhibits MraY to regulate lipid carrier distribution among competing pathways.
bioRxiv · Aug 1, 2023 · PreprintMicrobiology