A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for diagnosis of glanders infections
G. Wang, L. Glaser, N. E. Scott, Y. Fathy Mohamed, R. J. Ingram, K. Laroucau, M. A. Valvano
This paper constructs a glycoengineered antigen using a conserved Burkholderia O-glycosylation pathway to develop a highly specific diagnostic tool for glanders, achieving 100% specificity and over 88% sensitivity in detecting antibodies from infected horses.
bioRxiv · Aug 27, 2020Microbiology