Author

M. A. Valvano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 7

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 3 Organism:mouse· 3 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

N. E. Scott· 2 shared R. J. Ingram· 2 shared C. C. Oppy· 1 shared C. E. Bryant· 1 shared C. Oates· 1 shared D. Scanlan· 1 shared E. L. Hartland· 1 shared E. Schander· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

N. E. Scott

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Achromobacter Type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

K. Turton, H. Parks, P. Zarodkiewicz, M. A. Hamad, R. Dwane, G. Parau, R. J. Ingram, R. C. Coll, C. E. Bryant, M. A. Valvano

This study shows Achromobacter uses its Type 3 Secretion System to trigger pyroptosis via NLRC4 and NLRP3 inflammasomes, causing immunopathology in macrophages and mice.

Cell Reports · Aug 1, 2023Peer-reviewedMicrobiology

Glyceroglycolipids are essential for Burkholderia cenocepacia intracellular survival by preventing phagolysosome acidification

H. Shropshire, R. Guillonneau, Z. Han, R. Jones, S. Ahmed, I. Garcia Romero, I. Aberdeen, I. Nezis, M. A. Valvano, D. Scanlan, Y. Chen

bioRxiv · May 30, 2023 · PreprintMicrobiology

A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for diagnosis of glanders infections

G. Wang, L. Glaser, N. E. Scott, Y. Fathy Mohamed, R. J. Ingram, K. Laroucau, M. A. Valvano

This paper constructs a glycoengineered antigen using a conserved Burkholderia O-glycosylation pathway to develop a highly specific diagnostic tool for glanders, achieving 100% specificity and over 88% sensitivity in detecting antibodies from infected horses.

bioRxiv · Aug 27, 2020Microbiology

The DNA mimic protein BCAS0292 is involved in the regulation of virulence of Burkholderia cenocepacia

R. Dennehy, S. Dignam, S. McCormack, M. Romano, Y. Hou, L. Ardill, M. V. Whelan, Z. Drulis-Kawa, T. O Croinin, M. A. Valvano, R. Berisio, S. McClean

This study identifies BCAS0292 as a DNA-mimic protein in B. cenocepacia that regulates virulence and gene expression by altering DNA topology.

bioRxiv · Aug 6, 2020Microbiology

Characterization of the exopolysaccharide biosynthesis pathway in Myxococcus xanthus

M. Perez-Burgos, I. Garcia-Romero, J. Jung, E. Schander, M. A. Valvano, L. Sogaard-Andersen

This paper characterizes the exopolysaccharide (EPS) biosynthesis pathway in Myxococcus xanthus, identifying key enzymes and showing their role in motility and fruiting body formation.

bioRxiv · Jun 8, 2020Microbiology

Loss of O-linked protein glycosylation in Burkholderia cenocepacia impairs biofilm formation and siderophore production via alteration of quorum sensing regulation

C. C. Oppy, L. Jebeli, M. Kuba, C. Oates, R. A. Strugnell, L. Edgington-Mitchell, M. A. Valvano, E. L. Hartland, H. J. Newton, N. E. Scott

This paper shows that loss of O-linked glycosylation in B. cenocepacia disrupts quorum sensing, leading to reduced biofilm formation and siderophore production.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies diffusible signal factor analogues

S.-q. An, J. Murtagh, K. B. Twomey, M. K. Gupta, T. P. O'Sullivan, R. Ingram, M. A. Valvano, J.-l. Tang

This study investigates DSF analogues' effects on Pseudomonas aeruginosa's antibiotic sensitivity and biofilm formation, identifying potential lead compounds for antibiotic adjuvants.

bioRxiv · Apr 3, 2018Microbiology