Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation
P. P. Kulkarni, R. K. Alluri, M. Godwin, G. L. Forbes, A. Merkulova, A. Vijay, M. Palihati, S. Kundu, Y. J. Shim, A. H. Schmaier, M. Holinstat, S. J. Cameron, K. R. McCrae
This study shows that β2GPI-deficient mice are protected from thrombosis and have reduced PAR3-facilitated platelet activation, suggesting β2GPI enhances PAR3's role in thrombin-induced platelet activation.
Blood · May 1, 2025Peer-reviewedCell Biology