S. Kundu

Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation

This study shows that β2GPI-deficient mice are protected from thrombosis and have reduced PAR3-facilitated platelet activation, suggesting β2GPI enhances PAR3's role in thrombin-induced platelet activation.

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

This study shows that prior exposure to saprophytic Leptospira reduces severe leptospirosis symptoms and kidney fibrosis when mice are later infected with a pathogenic serovar.

Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility

This study compares semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility, finding no overall association but highlighting Flavobacterium's potential role.

NPZfc: An ecological relation based fish catch prediction model using Artificial Neural Network

The paper introduces NPZfc, an ANN model predicting planktivorous fish catch using ecological relationships, achieving high accuracy with limited data.

Potential use of Sodium Butyrate (SB) as an anti-virulence agent against Vibrio cholerae targeting ToxT virulence protein.

This paper shows sodium butyrate suppresses virulence in Vibrio cholerae by inhibiting ToxT-DNA binding and reducing toxin production, suggesting it as an anti-virulence agent.

Macrophages form integrin-mediated adhesion rings to pinch off surface-bound objects for phagocytosis

This study shows macrophages form integrin-mediated adhesion rings to engulf surface-bound objects by local actin polymerization, not myosin II.

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

This study identifies recurring EPHB1 mutations in cancers, showing some impair cell compartmentalisation while others enhance it, with functional consequences on signalling pathways.

Toxic metal uptake by oyster mushrooms grown in sugarcane bagasse

This study investigates metal uptake by oyster mushrooms grown on sugarcane bagasse, finding biomagnification of heavy metals in mushrooms compared to the substrate.

Small cell lung cancer co-culture organoids provide insights into cancer cell survival after chemotherapy

This paper develops a 3D SCLC co-culture organoid model to study chemotherapy resistance and fibroblast interactions in relapsed SCLC.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

The paper develops brain region-specific neural spheroids for disease modeling and drug screening, demonstrating their utility in Alzheimer's, Parkinson's, and Opioid Use Disorder.

Infected I. scapularis nymphs maintained in prolonged questing under optimal environmental conditions for one year can transmit B. burgdorferi to uninfected hosts

Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein

This study identifies the substrate recognition mechanism of LipB, showing it primarily binds the C8-phosphopantetheine arm and weakly interacts with apo-ACP.

Implicitly Learned Higher Order Associations Differentiates Recent and Remote Retrieval of Temporal Order Memory

This study investigates temporal order memory in mice, showing that animals form both explicit and implicit higher order associations, with implicit associations declining with temporal distance.

Nuclear biocondensate-forming lncRNA and cellular stress surveillance shape host cancer susceptibility

This study identifies hsr{omega} and its human homologs as key regulators of cancer susceptibility through stress response pathways in Drosophila and humans.