Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
K. Suda, Y. Moriyama, Y. Masukagami, N. B. Razali, Y. Chiu, K. Nishimura, H. Barbee, H. Takase, S. Sugiyama, Y. Sato, T. Higashiyama, Y. Johmura, M. Nakanishi, K. Kono
This study shows plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts through the ESCRT pathway and Ca2+-p53 axis.
bioRxiv · Mar 26, 2021Cell Biology