Author

M. Nakanishi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

E. Mori· 4 shared H. Nanaura· 4 shared K. Sugie· 4 shared A. Nishiyama· 3 shared K. Arita· 3 shared M. Matsubayashi· 3 shared S. Kikuchi· 3 shared S. Kobashigawa· 3 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

E. Mori

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3

N. Shiraishi, T. Konuma, Y. Chiba, S. Hokazono, N. Nakamura, M. H. Islam, M. Nakanishi, A. Nishiyama, K. Arita

This study compares the structural and functional differences between human and mouse DPPA3 in binding to UHRF1 PHD finger, showing weaker human DPPA3 binding and reduced inhibition of UHRF1 chromatin binding.

bioRxiv · Jan 11, 2024Biochemistry

Zinc finger domains bind low-complexity domain polymers

N. Iguchi, N. Isozumi, Y. Hattori, T. Imamura, M. So, H. Nanaura, T. Kiriyama, N. Eura, M. Yamaoka, M. Nakanishi, M. Mori, S. Ohki, H. Kumeta, H. Koga, M. Watabe, , E. Mori

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

bioRxiv · Oct 29, 2023 · PreprintBiochemistry

Structural basis for activation of DNMT1

A. Kikuchi, H. Onoda, K. Yamaguchi, S. Kori, S. Matsuzawa, Y. Chiba, S. Tanimoto, S. Yoshimi, H. Sato, A. Yamagata, M. Shirouzu, N. Adachi, J. Sharif, H. Koseki, A. Nishiyama, , K. Arita

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

bioRxiv · Jun 16, 2022Biochemistry

Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger

K. Hata, N. Kobayashi, K. Sugimura, W. Qin, D. Haxholli, Y. Chiba, S. Yoshimi, G. Hayashi, H. Onoda, T. Ikegami, C. B. Mulholland, A. Nishiyama, M. Nakanishi, H. Leonhardt, T. Konuma, K. Arita

This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.

bioRxiv · Jun 14, 2022Biochemistry

Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

K. Suda, Y. Moriyama, Y. Masukagami, N. B. Razali, Y. Chiu, K. Nishimura, H. Barbee, H. Takase, S. Sugiyama, Y. Sato, T. Higashiyama, Y. Johmura, M. Nakanishi, K. Kono

This study shows plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts through the ESCRT pathway and Ca2+-p53 axis.

bioRxiv · Mar 26, 2021Cell Biology

C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture

T. Shiota, R. Nagata, S. Kikuchi, H. Nanaura, M. Matsubayashi, M. Nakanishi, S. Kobashigawa, K. Nagayama, K. Sugie, Y. Yamashiro, E. Mori

This study investigates how C9orf72-derived PR poly-dipeptides alter cytoskeletal structure and cell mechanics in mammalian cells.

bioRxiv · Oct 14, 2020 · PreprintBiochemistry

ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway

S. S. Ito, Y. Nakagawa, M. Matsubayashi, Y. M. Sakaguchi, S. Kobashigawa, T. K. Matsui, H. Nanaura, M. Nakanishi, F. Kitayoshi, S. Kikuchi, A. Kajihara, S. Tamaki, K. Sugie, G. Kashino, A. Takahashi, , T. Kirita

This study shows that ATR inhibition increases 5-FU sensitivity in cancer cells, independent of DNA repair pathways.

bioRxiv · Apr 20, 2020 · PreprintCancer Biology

Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

M. Matsubayashi, Y. M. Sakaguchi, Y. Sahara, H. Nanaura, S. Kikuchi, A. Ashari, L. Bui, S. Kobashigawa, M. Nakanishi, R. Nagata, T. K. Matsui, G. Kashino, M. Hasegawa, S. Takasawa, M. Eriguchi, , E. Mori

The paper identifies 27-hydroxycholesterol's role in regulating URAT1/SLC22A12 gene expression through estrogen response elements, linking cholesterol metabolism to serum uric acid levels.

bioRxiv · Nov 6, 2019 · PreprintBiochemistry

Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors

K. Nishino, Y. Arai, K. Takasawa, M. Toyoda, M. Yamazaki-Inoue, T. Sugawara, H. Akutsu, K. Nishimura, M. Ohtaka, M. Nakanishi, A. Umezawa

The paper compares epigenetic differences in human iPSCs generated by three different vectors and finds Sendai virus generates the fewest aberrant methylation sites.

bioRxiv · Jun 25, 2018Cell Biology