Sequence grammar underlying unfolding and phase separation of globular proteins
K. M. Ruff, Y. H. Choi, D. Cox, A. R. Ormsby, Y. Myung, D. B. Ascher, S. E. Radford, R. V. Pappu, D. M. Hatters
The paper investigates how sequence grammars of unfolded globular proteins drive phase separation and formation of UPODs, highlighting the role of hydrophobic residues and their impact on disease-related interactions.
bioRxiv · Aug 20, 2021 · PreprintBiophysics