Author

D. B. Ascher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

D. E. V. Pires· 2 shared D. M. Hatters· 2 shared K. Artavanis-Tsakonas· 2 shared Y. Myung· 2 shared A. A. Vinogradov· 1 shared A. Elofsson· 1 shared A. Frost· 1 shared A. O. Zalevsky· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

D. E. V. Pires

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

H. R. King, M. Bycroft, T.-B. Nguyen, G. Kelly, A. A. Vinogradov, P. J. Rowling, K. Stott, D. B. Ascher, H. Suga, L. S. Itzhaki, K. Artavanis-Tsakonas

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

bioRxiv · Jan 11, 2024 · PreprintBiophysics

A broad-spectrum α-glucosidase of glycoside hydrolase family 13 from Marinovum sp., a member of the Roseobacter clade

J. Li, J. W.- Y. Mui, B. M. da Silva, D. E. V. Pires, D. B. Ascher, N. Madiedo Soler, E. D. Goddard-Borger, S. J. Williams

The paper identifies and characterizes a broad-spectrum α-glucosidase from Marinovum sp., revealing its unexpected activity on various disaccharides rather than sulfosugars.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis

C. Smith, R. Henrici, M. Karpiyevich, M. R. Ansbro, J. Hoshizaki, G. J. van der Heden van Noort, D. B. Ascher, C. J. Sutherland, M. C. S. Lee, K. Artavanis-Tsakonas

The paper investigates mutations in Plasmodium UBP-1 linked to drug resistance and shows how these mutations affect ubiquitin hydrolysis and parasite fitness.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology

A structural biology community assessment of AlphaFold 2 applications

M. Akdel, D. E. Pires, E. Porta-Pardo, J. Janes, A. O. Zalevsky, B. Meszaros, P. Bryant, L. L. Good, R. A. Laskowski, G. Pozzati, A. Shenoy, W. Zhu, P. Kundrotas, V. Ruiz-Serra, C. H. Rodrigues, , P. Beltrao

This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.

bioRxiv · Sep 26, 2021 · PreprintBiophysics

Sequence grammar underlying unfolding and phase separation of globular proteins

K. M. Ruff, Y. H. Choi, D. Cox, A. R. Ormsby, Y. Myung, D. B. Ascher, S. E. Radford, R. V. Pappu, D. M. Hatters

The paper investigates how sequence grammars of unfolded globular proteins drive phase separation and formation of UPODs, highlighting the role of hydrophobic residues and their impact on disease-related interactions.

bioRxiv · Aug 20, 2021 · PreprintBiophysics

Modelling tuberculosis drug resistance amplification rates in high-burden settings

M. Karmakar, R. Ragonnet, D. B. Ascher, J. M. Trauer, J. T. Denholm

The paper develops a four-strain epidemiological model to estimate drug resistance amplification and transmission rates in tuberculosis, finding that transmission contributes significantly to resistance in high-burden settings.

bioRxiv · Jan 12, 2021 · PreprintMicrobiology

Mercury methylation by metabolically versatile and cosmopolitan marine bacteria

H. Lin, D. B. Ascher, Y. Myung, C. H. Lamborg, S. J. Hallam, C. M. Gionfriddo, K. E. Holt, J. W. Moreau

This study identifies novel marine bacteria capable of mercury methylation, revealing their broader habitat range and oxygen tolerance.

bioRxiv · Jun 3, 2020Microbiology

Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

X. Sui, D. E. V. Pires, S. Nie, G. Vecchi, M. Vendruscolo, D. B. Ascher, G. E. Reid, D. M. Hatters

The paper measures proteome solubility changes in Neuro2a cells under various protein homeostasis stresses and finds widespread remodelling with specific patterns of solubility shifts.

bioRxiv · Jul 26, 2019Biochemistry