S. E. Radford

In situ cryo-electron tomography of beta-amyloid and tau in post-mortem Alzheimer's disease brain

This study uses cryo-electron tomography to examine the in situ structure of beta-amyloid and tau in Alzheimer's disease brain tissue, revealing distinct structural features and spatial organization.

Energy landscape steering mediates dynamic coupling in ATP-driven protein translocation by the bacterial Sec machinery

This study uses single-molecule fluorescence to show that SecYEG dynamically couples with SecA through energy landscape steering, enhancing protein translocation efficiency.

Protein-lipid charge interactions control the folding of OMPs into asymmetric membranes

The paper investigates how lipid charge asymmetry affects the folding of bacterial outer membrane proteins (OMPs) and identifies key residues involved in this process.

Tau amyloid polymorphism is shaped by local structural propensities of its protein sequence

The paper identifies a C-terminal tau peptide that adopts polymorphic conformations contributing to disease-specific tau filament folds and propagation.

Cooperative electrolyte-PEG interactions drive the signal amplification in a solid-state nanopore

This paper enhances nanopore signal-to-noise ratio by modifying the solution with PEG and optimizing the supporting electrolyte, enabling detection of short dsDNA.

Sequence grammar underlying unfolding and phase separation of globular proteins

The paper investigates how sequence grammars of unfolded globular proteins drive phase separation and formation of UPODs, highlighting the role of hydrophobic residues and their impact on disease-related interactions.

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

This paper shows Brazilin inhibits alpha-synuclein fibril formation and reduces toxicity in Parkinson's disease by altering conformational equilibrium.

PyXlinkViewer: a flexible tool for visualisation of protein chemical crosslinking data within the PyMOL molecular graphics system

PyXlinkViewer maps XL-MS data onto protein structures and models, enabling visualization and analysis of crosslinks and inter-residue distances.

Inter-domain dynamics in the chaperone SurA and multi-site binding to its unfolded outer membrane protein clients

This study investigates the conformational dynamics of SurA and its interaction with unfolded OMP clients using multiple biophysical techniques.

Structural insight into the formation of lipoprotein-β-barrel complexes by the β-barrel assembly machinery

The paper reports the crystal structure of BamA in complex with RcsF, revealing a push-and-pull mechanism for RcsF export and providing insights into BAM function and antibiotic development.

Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation

This study shows collagen I weakly interacts with β2-microglobulin, promoting conformational exchange that leads to amyloid formation.

Dynamic action of the Sec machinery during initiation, protein translocation and termination revealed by single molecule fluorescence

This study uses single molecule FRET to analyze Sec machinery dynamics during protein translocation, revealing initiation, transport, and termination phases with specific roles for SecA and ATP hydrolysis.