Author

Y. N. Degefu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:machine learning (classical)· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

B. B. Aldridge· 3 shared J. Larkins-Ford· 3 shared N. Van· 3 shared A. Sokolov· 2 shared C. M. Thorpe· 1 shared D. Stone· 1 shared F. P. Maurer· 1 shared H. Poonawala· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

B. B. Aldridge

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Author profile →

3 papers

Recent·Most cited

Novel synergies and isolate specificities in the drug interactions landscape of Mycobacterium abscessus

N. Van, Y. N. Degefu, P. A. Leus, J. Larkins-Ford, J. Klickstein, F. P. Maurer, D. Stone, H. Poonawala, C. M. Thorpe, T. C. Smith, B. B. Aldridge

This study systematically measures drug interactions in Mycobacterium abscessus to identify synergistic combinations and highlight strain-specific responses.

bioRxiv · Dec 12, 2022Microbiology

Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements

J. Larkins-Ford, Y. N. Degefu, N. Van, A. Sokolov, B. B. Aldridge

The paper uses pairwise drug response data to train machine learning models predicting effective tuberculosis drug combinations, revealing design principles for rational combination therapy.

bioRxiv · Dec 5, 2021Microbiology

Systematic measurement of combination drug landscapes to predict in vivo treatment outcomes for tuberculosis

J. Larkins-Ford, T. Greenstein, N. Van, Y. N. Degefu, M. C. Olson, A. Sokolov, B. B. Aldridge

The paper systematically measures drug combinations to predict tuberculosis treatment outcomes using in vitro models and machine learning.

bioRxiv · Feb 3, 2021Microbiology