Transition to the structurally vulnerable nuclear state is an integral part of mouse embryonic development
T. Masahito, R. Sakanoue, A. Takasu, N. Watanabe, Y. Shimamoto, K. Miyamoto
The paper shows that mouse embryonic nuclei become structurally and mechanically vulnerable at the 2-cell stage due to lamin B1 loss via autophagy, essential for chromatin organization and zygotic genome activation.
bioRxiv · Feb 20, 2023 · PreprintCell Biology