Pseudogene-mediated DNA demethylation leads to oncogene activation
J. Kwon, Y. V. Liu, C. Gao, M. A. Bassal, A. I. Jones, J. Yang, Z. Chen, Y. Li, H. Yang, L. Chen, A. Di Ruscio, Y. Tay, L. Chai, D. G. Tenen
This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.
bioRxiv · Jul 15, 2020Cancer Biology