Author

A. Di Ruscio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

D. G. Tenen· 3 shared A. K. Ebralidze· 2 shared B. Q. Trinh· 2 shared E. van der Kouwe· 2 shared G. Heller· 2 shared H. Yang· 2 shared M. A. Bassal· 2 shared P. B. Staber· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

D. G. Tenen

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3 papers

Recent·Most cited

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter

E. van der Kouwe, G. Heller, A. Czibere, L. H. Castilla, R. Delwel, A. Di Ruscio, A. K. Ebralidze, M. Forte, L. Kazianka, C. Kornauth, T. Le, K. Lind, I. A. Monteiro Barbosa, A. Pichler, J. A. Pulikkan, , P. B. Staber

The paper shows that CBF fusions in AML activate the PU.1 antisense promoter, reducing sense PU.1 transcription and blocking myeloid differentiation, similar to T-cell differentiation.

Blood · Oct 14, 2021Peer-reviewedCancer Biology

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

B. Q. Trinh, S. Ummarino, A. K. Ebralidze, E. van der Kouwe, M. A. Bassal, T. M. Nguyen, R. Coffey, D. E. Tenen, E. Fabiani, C. Gurnari, C.-S. Wu, V. E. Angarica, Y. Zhang, L. Ying, H. Yang, , D. G. Tenen

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

bioRxiv · Jul 24, 2020Cancer Biology

Pseudogene-mediated DNA demethylation leads to oncogene activation

J. Kwon, Y. V. Liu, C. Gao, M. A. Bassal, A. I. Jones, J. Yang, Z. Chen, Y. Li, H. Yang, L. Chen, A. Di Ruscio, Y. Tay, L. Chai, D. G. Tenen

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

bioRxiv · Jul 15, 2020Cancer Biology