L. Chai

Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains Kras mutant intestinal neoplasia

This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.

Single-molecule digital sizing of proteins in solution

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome

This study identifies the cellular origin of aberrant SALL4 expression in MDS using mass cytometry, showing it is mainly in HSPC and myeloid lineages, with SALL4/p53 co-expression linked to TP53 mutations.

Molecular architecture of the TasA biofilm scaffold in Bacillus subtilis

This study reveals the molecular structure of TasA biofilm scaffolds in Bacillus subtilis, showing they form β-sheet-rich filaments through donor strand complementation, essential for biofilm formation.

Inhibitory effect of EGCG-AgNPs and their lysozyme bioconjugates on biofilm formation and cytotoxicity

This study shows that EGCG-AgNPs inhibit Bacillus subtilis biofilm formation without cytotoxicity, while their lysozyme conjugates inhibit biofilms but are cytotoxic.

AlphaFold Protein Structure Database for Sequence-Independent Molecular Replacement

The paper tests if AlphaFold-predicted protein structures can be used for sequence-independent molecular replacement in crystallography, successfully determining two unknown contaminant structures.

Multiscale X-ray study of Bacillus subtilis biofilms reveals interlinked structural hierarchy and elemental heterogeneity

This study uses multiscale X-ray techniques to reveal structural and elemental heterogeneity in Bacillus subtilis biofilms, linking ECM properties to metal ion distribution and sporulation.

Gene flux and acid-imposed selection are the main drivers of antimicrobial resistance in broiler chicks infected with Salmonella enterica serovar Heidelberg

This study shows that antibiotic-resistant Salmonella can acquire resistance from gut commensals in antibiotic-free broiler chicks, driven by horizontal gene transfer and acidic selection pressure, suggesting antibiotic reduction alone may not limit resistance spread.

Pseudogene-mediated DNA demethylation leads to oncogene activation

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.