G-quadruplex dynamics contribute to epigenetic regulation of mitochondrial function
Micol Falabella, Jill E. Kolesar, Irene M. Xiang, Timothy R. W. Wang, William T. Horne, Callen T. Wallace, L. Sun, Y. V. Taguchi, C. Wang, Joshua Turek-Herman, Claudette M. St. Croix, Neal Sondheimer, Liliya A. Yatsunyk, F. Brad Johnson, Brett A. Kaufman
This study shows that G-quadruplex structures in mtDNA regulate mitochondrial function, and RHPS4, a G4 ligand, affects mtDNA replication, transcription, and respiratory function in normal cells.
bioRxiv · Jul 13, 2018 · PreprintMolecular Biology