F. Brad Johnson

A Measure of Transcriptional Dyscoordination for Quantifying Aging in Single Cells

This paper introduces a measure of transcriptional dyscoordination to quantify aging in single cells, showing it increases with age and is linked to cellular processes like senescence and genome instability.

Orthotopic Transplantation and Engraftment of Human Induced Pluripotent Stem Cell-Derived Alveolar Progenitor Cells into Murine Lungs

This paper demonstrates the orthotopic transplantation of human induced pluripotent stem cell-derived alveolar progenitor cells into murine lungs to create a humanized lung model.

G-quadruplex dynamics contribute to epigenetic regulation of mitochondrial function

This study shows that G-quadruplex structures in mtDNA regulate mitochondrial function, and RHPS4, a G4 ligand, affects mtDNA replication, transcription, and respiratory function in normal cells.