Claudette M. St. Croix

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

This study shows that germline loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and hypothermia, mediated by NHR-49/PPAR.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

This study shows that G-quadruplex structures in mtDNA regulate mitochondrial function, and RHPS4, a G4 ligand, affects mtDNA replication, transcription, and respiratory function in normal cells.