Keratinocyte-tethering modification for biologics enables location-precise treatment in mouse vitiligo
Y.-C. Hsueh, Y. Wang, R. L. Riding, D. E. Catalano, Y.-J. Lu, J. M. Richmond, D. L. Siegel, M. Rusckowski, J. R. Stanley, J. E. Harris
This paper develops a bispecific antibody tethered to keratinocytes to locally block IFNγ in vitiligo, showing improved skin retention and reduced systemic effects.
bioRxiv · Feb 28, 2022 · PreprintImmunology