Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity
Y. Heo, E. Yoon, Y.-E. Jeon, J.-H. Yun, N. Ishimoto, H. Woo, S.-Y. Park, J.-J. Song, W. Lee
The paper reports the cryo-EM structure of human SSTR2 bound to somatostatin, revealing ligand binding specificity and interactions with Gi proteins.
bioRxiv · Jan 5, 2022Biophysics