Analysis of the SARS-CoV-2 spike protein revealed that blocked receptor-binding domain antigenicity decreases the production of neutralizing antibodies in vivo
Y.-F. Mei, Q. Zhang, M. E. Hammond, J. Song, Z. Fang, H. Zhao, M. Landstrom
This study shows that ACE2 binding blocks RBD antigenicity, reducing neutralizing antibody production, and suggests improving vaccine efficacy by exposing RBD immunogenicity.
bioRxiv · Feb 23, 2023 · PreprintMicrobiology