J. Song

Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

This paper engineers one-signal-activated TILs with CD3ζ-CD28 chimeras to enhance antitumor efficacy in immunotherapy.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

This paper presents a 3D-printed composite scaffold system for bone regeneration that accelerates ECM and mineralized osteoid deposition in vivo.

The kinematics and aerodynamics of hinged wing of honeybees during takeoff

This study analyzes honeybee wing kinematics during takeoff, revealing key parameters and the role of hinged wings in thrust generation.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

The paper identifies single missense mutations in Vi capsule synthesis genes that confer hypervirulence to Salmonella Typhi by altering capsule length or acetylation.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Armillaria korhonenii, the sixteenth biological species of Armillaria from China

The paper describes a new species of Armillaria, Armillaria korhonenii, based on phylogenetic, morphological, and mating test evidence, identifying it as the sixteenth biological species in China.

Predicting Pseudomonas aeruginosa drug resistance using artificial intelligence and clinical MALDI-TOF mass spectra

This paper uses AI with MALDI-TOF mass spectra to predict antibiotic resistance in Pseudomonas aeruginosa, achieving high accuracy for specific drug combinations.

Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser

This paper presents the structure of ATP-bound RNA Polymerase II at 3.0 Å resolution using a free-electron laser, revealing new insights into substrate binding and metal coordination in the active site.

Structural basis for the allosteric regulation and dynamic assembly of DNMT3B

This study determines the cryo-EM structure of DNMT3B under various oligomerization states, revealing how its domains interact to regulate its assembly and function.

Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided analyses

The paper uses data-driven and model-guided analyses to optimize feed media for improved CHO cell growth and titer by identifying key amino acids and metabolic bottlenecks.

ATP energy-independentlymodulates the folding equilibrium of ALScausing C71G-hPFN1

This study investigates how ATP modulates the folding equilibrium of the ALS-causing C71G-hPFN1 mutant, revealing its role in inducing folding, inhibiting aggregation, and increasing stability.

Phenotypic plasticity of antibiotic resistance, metabolism byproduct utilization and the evolution of mutually beneficial cooperation in Escherichia coli

The paper shows that antibiotic-resistant E. coli can protect sensitive strains from antibiotics and that metabolic byproducts like indole can create mutualistic cooperation between resistant and sensitive strains.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

Human receptive endometrial assembloid for deciphering the implantation window

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

TPR domain assigns versatility of BcTir/Tpr system against viral infection

The paper identifies the BcTir/Tpr system in Bacillus cereus as a defense mechanism against phage infection, showing BcTpr's dual role in NAD+ depletion and cADPR isomer production.

Only Zn2+ and Fe2+ out of 12 cations can fold ALS-linked nascent hSOD1

This paper identifies Zn2+ and Fe2+ as the only cations among 12 tested that can induce folding of nascent hSOD1, with implications for ALS pathogenesis.

Activation of peroxisome proliferator-activated receptor-gamma prevents monocrotaline-induced pulmonary arterial hypertension by suppressing of nuclear factor-kappa B mediated autophagy

This study shows that activating PPAR-gamma reduces pulmonary arterial hypertension by inhibiting NF-kappa B-mediated autophagy in a rat model.

Multi-omic analysis of CIC's functional networks reveals novel interaction partners and a potential role in mitotic fidelity

This study uses multi-omic approaches to analyze CIC's functional networks, identifying novel interactions and revealing its role in mitotic fidelity and transcriptional splicing.

Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Analysis of the SARS-CoV-2 spike protein revealed that blocked receptor-binding domain antigenicity decreases the production of neutralizing antibodies in vivo

This study shows that ACE2 binding blocks RBD antigenicity, reducing neutralizing antibody production, and suggests improving vaccine efficacy by exposing RBD immunogenicity.

MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

Structural basis for inactivation of PRC2 by G-quadruplex RNA

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery

This study identifies Mco6 as a component of the mitochondrial sorting and assembly machinery, showing its interaction with Mdm10 and Mim1 and its role in TOM complex assembly.