Author

Y.-g. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 2 Cell Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

J. Sun· 8 shared Y. Xia· 8 shared S. Garrett· 4 shared D. Ogbu· 2 shared J. Zhang· 2 shared R. Lu· 2 shared C. Meng· 1 shared D. Zhou· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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8 shared papersCancer Biology

J. Sun

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Dysfunction of transfer RNA modifications in inflammatory bowel disease

J. Zhang, Y.-g. Zhang, Y. Xia, J. Sun

This study investigates the role of Q-tRNA modifications in inflammatory bowel disease, finding reduced QTRT1 expression and altered junction proteins in IBD patients and models.

bioRxiv · May 18, 2022 · PreprintCell Biology

Extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer

Y.-g. Zhang, J. Zhang, S. Deb, S. Garrett, Y. Xia, J. Sun

This study shows that intestinal vitamin D receptor deficiency promotes breast cancer by causing gut dysbiosis, increased inflammation, and microbial translocation.

bioRxiv · May 17, 2022 · PreprintCancer Biology

Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiota

S. Garrett, Y.-G. Zhang, Y. Xia, J. Sun

This study shows that intestinal epithelial Axin1 deficiency reduces susceptibility to colitis by altering gut microbiota composition and Paneth cell function.

bioRxiv · Mar 23, 2022Pathology

Dietary butyrate treatment enhances healthy metabolites by longitudinal untargeted metabolomic analysis in amyotrophic lateral sclerosis mice

D. Ogbu, Y.-g. Zhang, K. Claud, Y. Xia, J. Sun

This study uses longitudinal metabolomic analysis to show that butyrate treatment in ALS mice alters metabolites, inflammation, and microglia, suggesting potential therapeutic applications.

bioRxiv · Jan 15, 2022 · PreprintPhysiology

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

Y.-g. Zhang, D. Ogbu, S. Garrett, Y. Xia, J. Sun

This study shows that microbiome dysbiosis in ALS mice precedes motor neuron degeneration and affects intestinal neuromuscular function, with interventions improving symptoms.

bioRxiv · Jul 13, 2021Physiology

Vitamin D Receptor Upregulates Tight Junction Protein Claudin-5 against Tumorigenesis

Y.-g. Zhang, S. Garrett, R. Carroll, Y. Xia, J. Sun

This study links VDR regulation of Claudin-5 to intestinal barrier function and tumorigenesis in colorectal cancer, showing VDR deficiency reduces Claudin-5 and increases tumor formation.

bioRxiv · Apr 29, 2021 · PreprintCancer Biology

Salmonella Enteritidis Effector AvrA suppresses autophagy by reducing Beclin-1 protein

Y. Jiao, Y.-g. Zhang, Z. LIN, R. Lu, Y. Xia, C. Meng, Z. Pan, X. Xu, X.-a. Jiao, J. Sun

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

Frontiers in Immunology · Apr 17, 2020Peer-reviewedMicrobiology

Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK/STAT pathway in intestine

Y.-g. Zhang, R. Lu, S. Wu, I. Chatterjee, D. Zhou, Y. Xia, J. Sun

This study shows that intestinal VDR protects against dysbiosis and tumorigenesis by modulating the JAK/STAT pathway through microbiome interactions.

bioRxiv · Feb 18, 2020Cancer Biology