Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment
E.-H. Lin, C.-F. Hsu, Y.-H. Jan, T.-H. Lin, H.-Y. Chang, C.-M. Cheng, H.-J. Hsu, W.-W. Chen, B.-H. Chen, H.-F. Tsai, J.-J. Li, C.-Y. Huang, S.-H. Chuang, J.-M. Chang, M. Hsiao, C.-W. Wu
This study identifies BMI1 and MCL1 as key drivers of lung adenocarcinoma progression and demonstrates that targeting these proteins with a novel small-molecule inhibitor suppresses tumor growth in preclinical models.
bioRxiv · Oct 22, 2018 · PreprintCancer Biology