H.-Y. Chang

Protein N-Terminomics Reveals Major Proteases in Regulating Beige Adipocyte Differentiation

This study identifies proteases regulating beige adipocyte differentiation through N-terminomics and functional experiments.

Skopi: a simulation package for diffractive imaging of noncrystalline biomolecules

Skopi generates diffraction images for various XFEL experiments to aid in developing feedback mechanisms for non-crystalline biomolecular structure analysis.

Isolation of protein N-terminal peptides by charge-mediated position- elective enrichment using strong cation exchange chromatography

The paper introduces a method to enrich and profile protein N-terminal peptides using TrypN digestion and CHAMP-SCX chromatography, achieving high specificity and sensitivity in human cell lysates.

Comparative genomics: Dominant coral bacterium Endozoicomonas acroporae metabolizes Dimethylsulfoniopropionate (DMSP)

This study identifies and functionally characterizes DMSP metabolism in Endozoicomonas acroporae, confirming its role in the coral sulfur cycle.

Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation

This paper introduces MELDI, a method to identify and map lipid isomers using epoxidation and mass spectrometry, demonstrating its application in human serum and adipocytes.

Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment

This study identifies BMI1 and MCL1 as key drivers of lung adenocarcinoma progression and demonstrates that targeting these proteins with a novel small-molecule inhibitor suppresses tumor growth in preclinical models.

Quantifying platelet margination in diabetic blood flow

This study uses computational modeling to show that T2DM alters platelet margination through changes in RBC deformability, platelet size, flow rate, and WBC interactions.

Modeling Of Biomechanics And Biorheology Of Red Blood Cells In Type-2 Diabetes Mellitus

This study uses computational simulations to model biomechanical and rheological changes in red blood cells of T2DM patients, identifying a parametric model that captures key alterations in cell behavior.