What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks
T. I. Hung, Y.-J. Hsieh, W.-L. Lu, K.-P. Wu, C.-e. Chang
The paper identifies critical residues in protein-protein interactions through residue correlation networks and demonstrates a method to design high-affinity protein binders with improved selectivity and potency.
bioRxiv · Mar 15, 2023Biophysics