Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex
H. K. Bhargava, K. Tabata, J. K. Byck, M. Hamasaki, D. P. Farrell, I. Anishchenko, F. DiMaio, Y.-J. Im, T. Yoshimori, J. H. Hurley
This study determines the crystal structure of the Rubicon RH domain bound to Rab7-GTP, revealing its mechanism of autophagy inhibition and validating it as a therapeutic target.
bioRxiv · Apr 18, 2020Cell Biology