Author

D. P. Farrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:metabolism & bioenergetics· 2 Organism:yeast· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

F. DiMaio· 4 shared E. M. Lynch· 2 shared J. M. Kollman· 2 shared A. Horowitz· 1 shared A. J. Taylor· 1 shared A. M. Dosey· 1 shared A. W. Murray· 1 shared D. J. Kelly· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

F. DiMaio

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-EM Structures of CTP Synthase Filaments Reveal Mechanism of pH-Sensitive Assembly During Budding Yeast Starvation

J. M. Hansen, A. Horowitz, E. M. Lynch, D. P. Farrell, J. Quispe, F. DiMaio, J. M. Kollman

The paper uses cryo-EM to study CTP synthase filament assembly in yeast, revealing pH-sensitive mechanisms and their role in starvation response.

bioRxiv · Aug 25, 2021Biochemistry

Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex

H. K. Bhargava, K. Tabata, J. K. Byck, M. Hamasaki, D. P. Farrell, I. Anishchenko, F. DiMaio, Y.-J. Im, T. Yoshimori, J. H. Hurley

This study determines the crystal structure of the Rubicon RH domain bound to Rab7-GTP, revealing its mechanism of autophagy inhibition and validating it as a therapeutic target.

bioRxiv · Apr 18, 2020Cell Biology

The cryo-EM structure of the bacterial flagellum cap complex suggests a molecular mechanism for filament elongation.

N. S. Al-Otaibi, A. J. Taylor, D. P. Farrell, S. B. Tzokov, F. DiMaio, D. J. Kelly, J. R. C. Bergeron

The paper reports the cryo-EM structure of the Campylobacter jejuni flagellum cap complex and proposes a model for filament-cap interaction.

bioRxiv · Oct 17, 2019Microbiology

Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity

P. R. Stoddard, E. M. Lynch, D. P. Farrell, Q. A. Justman, A. M. Dosey, F. DiMaio, T. A. Williams, J. M. Kollman, A. W. Murray, E. C. Garner

Yeast glucokinase activity is limited by its polymerization, which is critical for cell viability during glucose refeeding.

bioRxiv · Jul 2, 2019 · PreprintBiochemistry