Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald B. Wetzel, Hilal Ahmed Lashuel, Gillian P. Bates, Helen R. Saibil
This study uses correlative light and electron microscopy to show that mutant huntingtin accumulates in endolysosomal organelles in presymptomatic Huntington's disease, altering endolysosomal homeostasis.
Acta Neuropathologica Communications · Apr 14, 2021Peer-reviewedNeuroscience