Author

Kirupa Sathasivam

UCL Queen Square Institute of Neurology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Gillian P. BatesiD· 5 shared Christian LandlesiD· 4 shared Edward J. SmithiD· 3 shared Georgina F OsborneiD· 3 shared Iulia M NitaiD· 3 shared Jemima M PhillipsiD· 3 shared María Cañibano-PicoiD· 3 shared Jonathan R. Greene· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Gillian P. BatesORCID

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5 papers

Recent·Most cited

Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington's disease

Georgina F Osborne, Edward J. Smith, Kirupa Sathasivam, Zixin Kang, Iulia M Nita, María Cañibano-Pico, Jemima M Phillips, Gillian P. Bates, Christian Landles

This study develops and evaluates two novel antibodies, 1B12 and 11G2, for more sensitive detection of HTT1a in Huntington's disease mouse models compared to the existing MW8 antibody.

Brain Communications · Jan 1, 2026Peer-reviewedNeuroscience

Lowering the HTT1a transcript as an effective therapy for Huntingtons disease

Aikaterini Smaragdi Papadopoulou, Julia F. Alterman, Christian Landles, Edward J. Smith, Faith Conroy, Jemima M Phillips, María Cañibano-Pico, Iulia M Nita, Georgina F Osborne, Arzo Iqbal, Sarah G. Aldous, Marie K. Bondulich, Casandra Gomez-Paredes, Kirupa Sathasivam, Daniel O’Reilly, , Gillian P. Bates

The paper shows that lowering HTT1a transcript levels delays molecular and neuropathological phenotypes in a Huntington's disease mouse model.

bioRxiv · Jun 10, 2025 · PreprintNeuroscience

Mutant HTT protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.

Christian Landles, Georgina F Osborne, Jemima M Phillips, María Cañibano-Pico, Iulia M Nita, Nadira S. Ali, Konstantin Bobkov, Jonathan R. Greene, Kirupa Sathasivam, Gillian P. Bates

The paper shows that mutant HTT levels decrease with CAG repeat expansion, suggesting therapeutic strategies should target HTT1a instead of full-length HTT.

Brain Communications · Jan 1, 2024Peer-reviewedNeuroscience

m6A RNA modification of mHtt intron 1 regulates the generation of Htt1a in Huntington's Disease

Anika Pupak, Irene Rodríguez-Navarro, Kirupa Sathasivam, Amelie Essmann, Ankita Singh, Daniel del Toro, Sílvia Ginés, Gillian P. Bates, Ulf Andersson Ørom, Eulàlia Martı́, Verónica Brito

This study investigates how m6A RNA modifications in Htt intron 1 regulate the production of the pathogenic Htt1a transcript in Huntington's Disease.

bioRxiv · Nov 10, 2023 · PreprintNeuroscience

Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease

Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald B. Wetzel, Hilal Ahmed Lashuel, Gillian P. Bates, Helen R. Saibil

This study uses correlative light and electron microscopy to show that mutant huntingtin accumulates in endolysosomal organelles in presymptomatic Huntington's disease, altering endolysosomal homeostasis.

Acta Neuropathologica Communications · Apr 14, 2021Peer-reviewedNeuroscience