Lipid peroxidation intrinsically induces mitochondrial iron overload via Bach1-HO-1 signaling to promote cardiac ferroptosis
Xiaoyun Guo, Yi Chen, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Kevin S. Zhang, Qinghang Liu
This study identifies a mechanism by which lipid peroxidation induces mitochondrial iron overload via Bach1-HO-1 signaling, promoting cardiac ferroptosis and dilated cardiomyopathy.
bioRxiv · Oct 15, 2025 · PreprintCell Biology