Author

Xiaoyun Guo

University of WashingtonPrimary ORCID profile (0000-0002-2307-637X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Xiaoyun GuoiD1 paper · MIT Computer Science and Artificial Intelligence Laboratory

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Qinghang LiuiD· 2 shared Alexandra M. WileyiD· 1 shared Eric A. EvangelistaiD· 1 shared Hui He· 1 shared Jing LiiD· 1 shared Kevin S. ZhangiD· 1 shared Libin XuiD· 1 shared Melissa A. KruegeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Qinghang LiuORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Transcriptional landscape of cardiac-specific Gpx4 deletion recapitulates human cardiomyopathy

Alexandra M. Wiley, Xiaoyun Guo, Yu Chen, Eric A. Evangelista, Melissa A. Krueger, Qinghang Liu, Libin Xu, Sina A. Gharib, Rheem A. Totah

This study examines the transcriptional effects of cardiac-specific Gpx4 deletion in mice and compares them to human cardiomyopathy, identifying ferroptosis-related pathways involved in heart disease.

bioRxiv · Mar 31, 2026 · PreprintGenomics

Lipid peroxidation intrinsically induces mitochondrial iron overload via Bach1-HO-1 signaling to promote cardiac ferroptosis

Xiaoyun Guo, Yi Chen, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Kevin S. Zhang, Qinghang Liu

This study identifies a mechanism by which lipid peroxidation induces mitochondrial iron overload via Bach1-HO-1 signaling, promoting cardiac ferroptosis and dilated cardiomyopathy.

bioRxiv · Oct 15, 2025 · PreprintCell Biology