Paralog interference contributes to the preservation of genetic redundancy
Angel F. Cisneros, Florian Mattenburger, Isabelle Gagnon‐Arsenault, Yacine Seffal, Lou Nielly‐Thibault, Alexandre K. Dubé, Maria del Mar Varela Vasquez, María Camila Muñoz Vega, Christian R. Landry
The paper shows that paralog interference enhances negative selection on loss-of-function mutations, preserving genetic redundancy over longer timescales.
bioRxiv · Jun 13, 2025 · PreprintEvolutionary Biology