Angel F. Cisneros

The paper examines how molecular interactions and activity-fitness functions determine phenotypic dominance in homomeric proteins.

The paper shows that paralog interference enhances negative selection on loss-of-function mutations, preserving genetic redundancy over longer timescales.

The paper identifies co-translational assembly as a mechanism promoting homomerization of paralogs, which enhances their functional divergence.

The paper shows that mutational biases can lead to the neutral evolution of heteromeric protein complexes over homomeric ones after gene duplication.

Toeholder is a software tool for automated design and in silico validation of toehold riboswitches, incorporating experimental data and molecular dynamics simulations.