Lou Nielly‐Thibault

The paper shows that paralog interference enhances negative selection on loss-of-function mutations, preserving genetic redundancy over longer timescales.

The paper shows that mutational biases can lead to the neutral evolution of heteromeric protein complexes over homomeric ones after gene duplication.

This paper develops a double selection strategy to improve CRISPR-Cas9 and base editing efficiency in yeast, enabling high-throughput mutagenesis screens.