Coronavirus nucleocapsid proteins differentially antagonize RIG-I-like receptor signaling to shape pathogenicity
Yajuan Rui, Yanpu Wang, Shiqi Chen, Yan Cao, Ying Hu, Si Shen, Qiang Ding, Jiaming Su, Xiao-Fang Yu
This study identifies that SARS-CoV and SARS-CoV-2 nucleocapsid proteins more effectively inhibit RIG-I-like receptor signaling than less pathogenic coronaviruses, enhancing viral replication and suggesting N protein targeting as an antiviral strategy.
bioRxiv · Oct 10, 2026 · PreprintMicrobiology