Author

Shiqi Chen

Second Affiliated Hospital of Zhejiang UniversityORCID 0000-0002-9129-0300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jiaming SuiD· 1 shared Qiang DingiD· 1 shared Si SheniD· 1 shared Xiao-Fang Yu· 1 shared Yajuan RuiiD· 1 shared Yan Cao· 1 shared Yanpu WangiD· 1 shared Ying Hu· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

Jiaming SuORCID

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1 paper

Recent·Most cited

Coronavirus nucleocapsid proteins differentially antagonize RIG-I-like receptor signaling to shape pathogenicity

Yajuan Rui, Yanpu Wang, Shiqi Chen, Yan Cao, Ying Hu, Si Shen, Qiang Ding, Jiaming Su, Xiao-Fang Yu

This study identifies that SARS-CoV and SARS-CoV-2 nucleocapsid proteins more effectively inhibit RIG-I-like receptor signaling than less pathogenic coronaviruses, enhancing viral replication and suggesting N protein targeting as an antiviral strategy.

bioRxiv · Oct 10, 2026 · PreprintMicrobiology