Aberrant neuron-OPC synaptic transmission and deficient myelination define sex bias in major depressive disorder
Cong Zeng, Yinong Li, Xiaorui Wang, Zhonghao Wu, Yan Shen, S Y Li, Shouyu Wang, Xiaoying Chen, Liting Wang, Ying Wan, Alexei Verkhratsky, Jianqin Niu
This study identifies sex-specific mechanisms in major depressive disorder, highlighting impaired neuron-OPC communication and myelination in females.
bioRxiv · Jun 16, 2026 · PreprintNeuroscience