Alexei Verkhratsky

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

The paper identifies a brain-tumour axis linking chronic stress to gastric cancer progression via NPY signalling, showing NPY1R as a therapeutic target.

This study identifies sex-specific mechanisms in major depressive disorder, highlighting impaired neuron-OPC communication and myelination in females.

The paper identifies a non-linear aging trajectory of Connexin43 in mouse and human brains, showing midlife elevation followed by late-life decline and glial remodeling.

This study investigates the role of P2X7 receptors in astrocytic atrophy following status epilepticus in mice, showing that P2X7R antagonism prevents astrocyte damage.

This study identifies CaCyBp as a neuronal receptor for S100A6, showing its role in modulating mitochondrial function and proteostasis in mouse and human brains.

This study shows that increasing ezrin in astrocytes makes mice more resilient to stress-induced depressive behaviors, while decreasing it increases susceptibility.

This study identifies S100A6 as a signaling molecule released by astrocytes that modulates neuronal development by inhibiting CaCyBp-mediated signaling, affecting proteostasis and neuritogenesis.

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

The paper identifies molecular changes in human astrocytes compared to non-human primates, revealing regulatory mechanisms linked to brain evolution.

This study identifies elastase (ELANE) as a driver of white matter damage in cerebral small vessel disease, showing its role in oligodendrocyte death and proposing it as a therapeutic target.

This study identifies microglial connexin43 hemichannels as a therapeutic target for Alzheimer's disease, showing that blocking them reduces pathology and cognitive impairment in mouse models.

This study investigates morphological changes in astrocytes during acute hepatic encephalopathy, finding hypertrophy of primary branches and atrophy of terminal leaflets linked to decreased expression of AQP4, phosphorylated ezrin, and profilin-1.

This study shows APP induces reactive astrogliosis in vitro and in vivo by remodeling intermediate filaments, enhancing cytokine production, and activating the IFN pathway.

This study identifies a network involving oligodendroglial precursors and immune cells that drives early demyelination in EAE, showing that targeting CCL4 disrupts this cycle.

The paper identifies a novel mechanism by which ependymocytes regulate cerebrospinal fluid (CSF) flow from the central nervous system to peripheral organs via the periaxonal pathway, mediated by serotonin signaling and F-actin polymerization.

This study investigates whether COVID-19 patient plasma affects BBB integrity in vitro using iBECs and finds no direct effect on TEER, but identifies elevated inflammatory factors in plasma.

This study shows electroacupuncture prevents astrocyte atrophy in mice with depression-like behaviors, suggesting astrocytes as a target for treatment.

This study shows that aging impairs astrocyte morphology and mitochondrial function in the human cerebral cortex, while neurons remain unaffected.

A high-fat diet increases astrocytic lipid content and branching, enhancing glutamate clearance and exploratory behavior in young mice.

This study shows that autocrine bFGF is essential for BCEC barrier function, while exogenous bFGF inhibits barrier resistance in a concentration-dependent manner.

This study shows that aging reduces astrocytic processes and function, which correlates with impaired synaptic plasticity in the hippocampus.

This study investigates the impact of iron from metal implants on neural cells, finding that iron accumulation affects neuronal function and may increase neurodegeneration risk.

The paper examines age-related changes in oligodendrocyte precursor cells (OPCs) in APP/PS1 mice, showing accelerated dystrophy and decay compared to non-transgenic controls.

This study investigates how iron ions affect calcium signaling in astrocytes through DMT1 and TFR, revealing mechanisms of neuroprotection against iron overload.

This study shows chronic sleep deprivation reduces astrocytic 5-HT2B receptors via P2X7 receptors, leading to depressive-like behaviors through increased arachidonic acid and PGE2 release.

This study shows that astrocytes from 3xTG-AD mice impair BBB integrity in vitro through paracrine mechanisms, as evidenced by reduced tight junction protein expression and TEER.

This study shows that fluoxetine alleviates alcohol addiction by reducing RNA editing of 5-HT2C receptors in astrocytes, thereby increasing ATP release and improving behavioral symptoms.