TIGAR DEFICIENCY ENHANCES CARDIAC RESILIENCE THROUGH EPIGENETIC PROGRAMMING OF PARKIN EXPRESSION
Yan Tang, Stanislovas S. Jankauskas, Li Liu, Xujun Wang, Alus M. Xiaoli, Fajun Yang, Gaetano Santulli, Daorong Feng, Jeffrey E. Pessin
This study shows TIGAR deficiency protects the heart through epigenetic regulation of Parkin, enhancing mitochondrial quality control and preventing cardiac damage.
JCI Insight · Feb 26, 2026Peer-reviewedMolecular Biology