Pharmacology & ToxicologyJournal of Pharmacology and Experimental TherapeuticsPeer-reviewed
Protective Effect of 2-Hydroxyestrone and2-Hydroxyestradiol Against Chemically-Induced Hepatotoxicity In Vitro and In Vivo
Xi Sun, Xiangyu Hao, Yi-Chen Jia…·Bao Ting Zhu
This study shows that 2-hydroxyestrone and 2-hydroxyestradiol protect against ferroptosis in hepatoma cells and acetaminophen-induced liver injury by inhibiting PDI activity and reducing NO, ROS, and lipid-ROS accumulation.