Prevalent cross-cell type QTL trans-regulatory genetic effects impacting innate lymphoid cells in the small intestine
Miao Xu, Kirk Gosik, Yang Zang, Orr Ashenberg, Chenhao Li, Hongjun Li, Kai Liu, Gary A. Churchill, Daniel M. Gatti, Kwangbom Choi, Vivek M. Philip, Daniel B. Graham, Kushal K. Dey, Heping Xu, Ramnik J. Xavier, Aviv Regev
The paper identifies genetic variants affecting innate lymphoid cells in the gut using single-cell RNA-seq and validates their regulatory roles across cell types.
bioRxiv · Apr 16, 2025 · PreprintGenetics