Author

Heping Xu

Westlake UniversityORCID 0000-0003-2149-7004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Dianyu CheniD· 2 shared Harinder SinghiD· 2 shared Aly Azeem KhaniD· 1 shared Andrew SoniniD· 1 shared Aviv RegeviD· 1 shared Bala RamaswamiiD· 1 shared Chenhao LiiD· 1 shared Daniel B. GrahamiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Dianyu ChenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition

Godhev K. Manakkat Vijay, Bala Ramaswami, Steven Gierlack, Nicholas A. Pease, Peter Gerges, Dianyu Chen, Kairavee Thakkar, Luis Mena Hernandez, Swapnil Keshari, Heping Xu, Nathan Salomonis, Jishnu Das, David M. Rothstein, Harinder Singh

This study shows Blimp1 restricts clonal dominance in germinal center B cells by controlling chromatin accessibility and BCR signaling during the light-to-dark zone transition.

Nature Immunology · Apr 20, 2026Peer-reviewedImmunology

Prevalent cross-cell type QTL trans-regulatory genetic effects impacting innate lymphoid cells in the small intestine

Miao Xu, Kirk Gosik, Yang Zang, Orr Ashenberg, Chenhao Li, Hongjun Li, Kai Liu, Gary A. Churchill, Daniel M. Gatti, Kwangbom Choi, Vivek M. Philip, Daniel B. Graham, Kushal K. Dey, Heping Xu, Ramnik J. Xavier, Aviv Regev

The paper identifies genetic variants affecting innate lymphoid cells in the gut using single-cell RNA-seq and validates their regulatory roles across cell types.

bioRxiv · Apr 16, 2025 · PreprintGenetics

Inferring cellular trajectories from scRNA-seq using Pseudocell Tracer

Derek J. Reiman, Heping Xu, Andrew Sonin, Dianyu Chen, Harinder Singh, Aly Azeem Khan

Pseudocell Tracer infers cellular trajectories from scRNA-seq data by simulating pseudocells in a virtual cell-state axis, revealing transcription factor dynamics during B cell immunoglobulin class switch recombination.

bioRxiv · Jun 26, 2020 · PreprintGenomics