Vivek M. Philip

CellMAGE deconvolves gene expression in multi-parent populations by leveraging known parental genetic contributions, outperforming existing methods in accuracy and efficiency.

The paper identifies genomic loci associated with cellular rhythms in Diversity Outbred mice using QTL mapping and connects them to circadian regulation and complex traits.

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

This study shows that multi-week digital home cage monitoring in rodents improves reproducibility by reducing noise and enhancing replication of genotype differences in activity.

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

The paper introduces mzrtsim, an R package that simulates raw metabolomics data for comparing software tools against a ground truth.

The paper identifies genetic variants affecting innate lymphoid cells in the gut using single-cell RNA-seq and validates their regulatory roles across cell types.

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

This study identifies and validates 22 genes that drive drug intake and related behavioral traits in mice through knockout screening and behavioral assays.

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

This study maps eQTLs in the striatum of Diversity Outbred mice and provides tools for querying genetic variants and co-expression networks related to striatal gene expression and addiction-related behaviors.

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.

The paper identifies six additional QTL that modify disease in Lamc2jeb/jeb mice, expanding the understanding of genetic modifiers of EB.

This study links gut microbiome composition and glutamate metabolism to cocaine self-administration in mice, showing sex-specific associations and functional relevance.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

This study maps ethanol sensitivity QTLs in Diversity Outbred mice using phenotyping and genotyping data to identify candidate genes for alcohol use disorders.

The paper measures cocaine-induced behavioral sensitization across genetically diverse Collaborative Cross strains and their founders, identifying significant heritability and phenotypic variation.

The paper identifies genetic loci associated with reversal learning phenotypes in Diversity Outbred mice, revealing a genome-wide significant QTL on chromosome 7.

The paper examines heritability of reward sensitivity and impulsivity traits in inbred mice and finds these traits are independent and heritable.

The paper identifies a genetic modifier locus, Bphse, that complements resistance to histamine sensitization in mice by analyzing Hrh1 alleles and using network-based methods.

The paper develops a neural network for automated mouse grooming behavior detection and uses it to study the genetic basis of grooming and its links to psychiatric traits.

This study examines heritability of ethanol consumption and pharmacokinetics in genetically diverse mouse strains, identifying heritable variation and sex-modulated genetic effects.

The paper introduces GBRS, a method to reconstruct diploid genomes and quantify gene expression in multi-parent populations using RNA-Seq data without requiring genotype information.

The paper identifies genetic factors influencing opioid-induced respiratory depression in mice using genetic mapping and functional analysis.

The paper identifies Rab3b as a gene influencing cocaine response and habituation in mice through integrative genomic analysis of multiple studies.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.

The paper identifies host-microbiome interactions using systems genetics in mice, revealing mechanisms of microbial involvement in disease.

This study identifies insertion sites in 40 transgenic mouse lines, revealing frequent disruptions of endogenous genes and structural variations.

This study shows that metformin prevents cardiac dysfunction in a mouse model of adult congenital heart disease under metabolic stress.