Design of high-affinity miniprotein antagonist targeting IL-4Ra for IL-4/IL-13 signal blockade
Yanghan Yu, Ningning Wang, Lingzhi Xu, Hongyun Wang, Ze Zhang, Bowen Yu
The paper designs high-affinity mini-protein antagonists targeting IL-4Ra using deep learning, achieving improved binding affinity and in vivo stability comparable to existing therapies.
bioRxiv · Aug 10, 2026 · PreprintSynthetic Biology