Ze Zhang

Histone modifications define distinct nucleosome positions in cell-free DNA

This paper identifies histone modification-associated nucleosome positions in cfDNA that correlate with tumor fraction and cancer state across multiple cancers.

Design of high-affinity miniprotein antagonist targeting IL-4Ra for IL-4/IL-13 signal blockade

The paper designs high-affinity mini-protein antagonists targeting IL-4Ra using deep learning, achieving improved binding affinity and in vivo stability comparable to existing therapies.

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

This study investigates how transcription factor subtypes in small cell lung cancer influence response and resistance to DLL3-targeted therapy, revealing subtype-specific mechanisms of resistance.

Integrated inference of cancer gene expression from cell-free plasma chromatin

APEX infers cancer gene expression from plasma cfChIP-seq data, outperforming existing methods and enabling subtype classification and biomarker identification.

Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling

This paper detects and monitors translocation renal cell carcinoma (tRCC) using plasma cell-free epigenomic profiling, achieving high accuracy in distinguishing tRCC from other cancers and healthy controls.

HalluDesign: Protein Optimization and de novo Design via Iterative Structure Hallucination and Sequence Design

HalluDesign optimizes and designs proteins using iterative structure hallucination and sequence design, achieving high success rates and structural accuracy in various tasks.

From Belief to Brain: How Growth Mindset Optimizes Cortico-Striatal Dynamics for Cognitive Development

This study shows that growth mindset enhances working memory development through optimized cortico-striatal network dynamics that balance flexibility and stability.