RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia
Tanxin Liu, Yanjie Li, Charley Wang, Cassandra J. Clark, Nathan Anderson, Erin L. Marcotte, Michael R. Lieber, Srividya Swaminathan, Joseph Leo Wiemels, Logan G. Spector, Vijay G. Sankaran, Carol Fries, Adam J. de Smith
The paper identifies RAG-mediated structural variants as a risk factor for relapse in pediatric B-ALL and T-ALL, independent of MRD status.
medRxiv · May 22, 2026 · PreprintGenetic & Genomic Medicine