Joseph Leo Wiemels

The paper uses single-cell multiomic analysis to identify genetic variants and regulatory disruptions linked to childhood B-cell acute lymphoblastic leukemia.

The paper identifies RAG-mediated structural variants as a risk factor for relapse in pediatric B-ALL and T-ALL, independent of MRD status.

This study investigates the impact of Indigenous American-like ancestry on acute lymphoblastic leukemia risk in Hispanic/Latino children, finding no global association but significant local haplotype effects.

This study evaluates polygenic risk scores for childhood ALL in Latinos, finding similar performance between non-Latino white and Latino samples but lower accuracy than a conventional model using known ALL-associated loci.

The paper identifies CoRSIVs with strong genetic control of methylation and links them to transposable elements and disease.

The paper introduces SCAVENGE, a method mapping causal variants to cellular contexts at single-cell resolution, identifying disease-relevant cell types and mechanisms.

This study identifies five novel genetic loci associated with childhood acute lymphoblastic leukemia through a trans-ethnic meta-analysis across four ethnic groups.

This study identifies genetic variants influencing blood cell traits linked to increased susceptibility to childhood acute lymphoblastic leukemia.